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ABSTRACT

Trends Microbiol 2002 Apr;10(4):193-9

Intracellular vs extracellular recognition of pathogens--common concepts in mammals and flies.

Girardin SE, Sansonetti PJ, Philpott DJ.
Pathogenie Microbienne Moleculaire and Immunite Innee et Signalisation, Institut Pasteur, 28 rue du Dr Roux, 75724 Cedex 15, Paris, France

There are common themes in innate immune defense systems across the animal and plant kingdoms. Pathogen recognition is commonly based on the identification of microbial molecular patterns by defined receptors and the subsequent activation of signaling pathways that initiate a defense response to fend off the invading microorganism. The existence of mammalian Toll-like receptors (TLRs) and the recent identification of two mammalian nucleotide-binding site leucine-rich repeat (NBS-LRR) proteins (NOD1 and NOD2) as intracellular sensors of bacterial products bring new insights into the possibility of extracellular versus intracellular pathogen recognition and signal transduction depending on the nature of the infection. The homology between TLRs and the Toll system in Drosophila suggests that conserved defense mechanisms are likely to be shared by diverse organisms.


PARA's SUMMARY

THIS PAPER DESCRIBES NOD-2, THE CROHN'S DISEASE SUSCEPTIBILITY GENE AS TO BE RESPONSIBLE FOR REGULATING THE HOST RESPONSE TO PATHOGENS. THIS AGAIN SUGGESTS AN INFECTIOUS NATURE OF CD.


Source: http://www.crohns.org/articles/2002_04_193-9_tm.htm   Contact PARA: http://www.crohns.org/contact.htm
Paratuberculosis Awareness & Research Association