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ABSTRACT

Curr Opin Microbiol 2002 Feb;5(1):76-80

Nods: a family of cytosolic proteins that regulate the host response to pathogens.

Inohara N, Ogura Y, Nunez G.
Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA. ino a umich.edu

Genetic variation in Nod2 is associated with susceptibility to Crohn's disease. Nod2 and its homologue, Nod1, are members of a growing family of cytosolic factors related to the apoptosis regulator Apaf-1 and a class of plant disease resistance proteins. Nod1 and Nod2 confer responsiveness to lipopolysaccharides and interact with RICK, a mediator of NF-kappaB activation. Nod1 and Nod2 and related Nods appear to regulate the host response to pathogens, a process that may be faulty in certain inflammatory diseases. Recent studies that suggest that Nods may be involved in the recognition of pathogen components in the cytosol of mammalian cells are reviewed


PARA's SUMMARY

THIS PAPER DESCRIBES NOD-2, THE CROHN'S DISEASE SUSCEPTIBILITY GENE AS TO BE RESPONSIBLE FOR REGULATING THE HOST RESPONSE TO PATHOGENS. THIS AGAIN SUGGESTS AN INFECTIOUS NATURE OF CD.


Source: http://www.crohns.org/articles/2002_02_76-80_com.htm   Contact PARA: http://www.crohns.org/contact.htm
Paratuberculosis Awareness & Research Association