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ABSTRACT

Lancet 2002 Jan 5;359(9300):62-9

Crohn's disease.

Shanahan F.
Department of Medicine, Clinical Sciences Building, Cork University Hospital, Cork, Ireland. F.shanahan a ucc.ie

Crohn's disease is a disorder mediated by T lymphocytes which arises in genetically susceptible individuals as a result of a breakdown in the regulatory constraints on mucosal immune responses to enteric bacteria. Regulation of immune reactivity to enteric antigens has improved understanding of the pathophysiological mechanisms of Crohn's disease, and has expanded therapeutic options for patients with this disorder. Disease heterogeneity is probable, with various underlying defects associated with a similar pathophysiological outcome. Although most conventional drug treatments are directed at modification of host response, therapeutic manipulation of the enteric flora is becoming a realistic option.


PARA's SUMMARY

THIS PAPER SUGGESTS THAT THERAPEUTIC MANIPULATION OF THE INTESTINAL FLORA IS NEEDED FOR THE SUCCESSFUL TREATMENT OF CD. THIS AGAIN SUGGESTS THAT CD IS INFECTIOUS IN NATURE.


Source: http://www.crohns.org/articles/2002_1_62-9_l.htm   Contact PARA: http://www.crohns.org/contact.htm
Paratuberculosis Awareness & Research Association