Association of Mycobacterium paratuberculosis in Crohn's disease and Johne's disease: A possible zoonotic threat
Mycobacterium paratuberculosis is the well-known etiologic agent of Johne's disease (JD), of the ruminants. In recent years, this organism has drawn attention due to its possible role in Crohn's disease (CD), a chronic inflammatory bowel disease of the human gastrointestinal tract. But the growing concern over the zoonotic potential of M. paratuberculosis is still not well established. The possible association of M. paratuberculosis with CD and its zoonotic significance has been reviewed in the light of isolation studies, experimental disease production, histopathological and immunological evidences, besides DNA sequence analysis. Food-borne exposure, the possible source of human infection, has also been discussed.
THIS ARTICLE CONCLUDES: "Until M. paratuberculosis is declared as non pathogenic to human beings, it should be handled with caution. If this is true, JD deserves to be dealt with seriously as a potential source of human pathogen from food hygiene and public health point of view."
Source: http://www.crohns.org/articles/2000_10_1076-81_cs.htm Contact PARA: http://www.crohns.org/contact.htm
Paratuberculosis Awareness & Research Association