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ABSTRACT

CURRENT SCIENCE, VOL. 79, NO. 8, 25:1076-81, OCTOBER 2000

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Association of Mycobacterium paratuberculosis in Crohn's disease and Johne's disease: A possible zoonotic threat

Tapas Kumar Goswami1, Siddhartha Narayan Joardar1, Gulab Chandra Ram1, Rabin Banerjee2 and Dhirendra Kumar Singh2
1Immunology Section and 2Division of Veterinary Public Health, Indian Veterinary Research Institute, Izatnagar 243 122, India

Mycobacterium paratuberculosis is the well-known etiologic agent of Johne's disease (JD), of the ruminants. In recent years, this organism has drawn attention due to its possible role in Crohn's disease (CD), a chronic inflammatory bowel disease of the human gastrointestinal tract. But the growing concern over the zoonotic potential of M. paratuberculosis is still not well established. The possible association of M. paratuberculosis with CD and its zoonotic significance has been reviewed in the light of isolation studies, experimental disease production, histopathological and immunological evidences, besides DNA sequence analysis. Food-borne exposure, the possible source of human infection, has also been discussed.


PARA's SUMMARY

THIS ARTICLE CONCLUDES: "Until M. paratuberculosis is declared as non pathogenic to human beings, it should be handled with caution. If this is true, JD deserves to be dealt with seriously as a potential source of human pathogen from food hygiene and public health point of view."


Source: http://www.crohns.org/articles/2000_10_1076-81_cs.htm   Contact PARA: http://www.crohns.org/contact.htm
Paratuberculosis Awareness & Research Association