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ABSTRACT

Clin Diagn Lab Immunol 1994 Mar;1(2):241-3

Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis

Vannuffel P, Dieterich C, Naerhuyzen B, Gilot P, Coene M, Fiasse R, Cocito C
Microbiology and Genetics Unit, University of Louvain, Brussels, Belgium

Sera from patients with Crohn's disease and control were analyzed by an enzyme-linked immunosorbent assay based on the Mycobacterium paratuberculosis-specific recombinant polypeptide a362. Anti-a362 immunoglobulin G (IgG) (P < 0.05) and IgA (P < 0.001) titers were higher in patients with Crohn's disease than in controls. A monomodal Gaussian distribution of anti-a362 IgA levels were found for controls, and a bimodal distribution was found for patients with Crohn's disease. An M. paratuberculosis etiology is suggested for the 36% of patients with Crohn's disease who had an anti-a362 IgA level higher than that of controls.


PARA's SUMMARY

DATA IN THIS PAPER SUGGESTS THAT MAP CAUSES AT LEAST 36% OF ALL CASES OF CD.


Source: http://www.crohns.org/articles/1994_03_241-3_cdli.htm   Contact PARA: http://www.crohns.org/contact.htm
Paratuberculosis Awareness & Research Association