Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis
Sera from patients with Crohn's disease and control were analyzed by an enzyme-linked immunosorbent assay based on the Mycobacterium paratuberculosis-specific recombinant polypeptide a362. Anti-a362 immunoglobulin G (IgG) (P < 0.05) and IgA (P < 0.001) titers were higher in patients with Crohn's disease than in controls. A monomodal Gaussian distribution of anti-a362 IgA levels were found for controls, and a bimodal distribution was found for patients with Crohn's disease. An M. paratuberculosis etiology is suggested for the 36% of patients with Crohn's disease who had an anti-a362 IgA level higher than that of controls.
DATA IN THIS PAPER SUGGESTS THAT MAP CAUSES AT LEAST 36% OF ALL CASES OF CD.
Source: http://www.crohns.org/articles/1994_03_241-3_cdli.htm Contact PARA: http://www.crohns.org/contact.htm
Paratuberculosis Awareness & Research Association