RETURN
TO
INDEX
RETURN
TO
INDEX

ABSTRACT

Clin Exp Immunol 1991 Feb;83(2):320-5

Induction of suppressor cells by Mycobacterium paratuberculosis antigen in inflammatory bowel disease.

Ebert EC, Bhatt BD, Liu S, Das KM.
Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903-0019

We studied the M. paratuberculosis-induced proliferation and suppressor cell generation by peripheral blood lymphocytes from patients with inflammatory bowel disease. Peripheral blood lymphocytes were separated from 33 patients with Crohn's disease, 18 with ulcerative colitis, nine with other intestinal diseases, and five with autoimmune disorders. Proliferation of peripheral blood lymphocytes from normal individuals in response to 10 micrograms/ml of M. paratuberculosis antigen was reduced by depletion of CD4+ T cells. The ability of M. paratuberculosis antigen to suppress concanavalin A-induced proliferation (expressed as a percentage suppression) was reduced by depletion of CD8+ T cells. This suppression was the same whether peripheral blood lymphocytes were from normal individuals, patients with intestinal diseases other than inflammatory bowel disease, or patients with autoimmune disorders (47 +/- 14%, 44 +/- 24%, and 30 +/- 26%, respectively). In contrast, the suppression induced by M. paratuberculosis for patients with Crohn's disease and ulcerative colitis (66 +/- 22% and 67 +/- 22%) was much greater than that for normal individuals (P less than 0.001). In particular, lymphocytes from patients with active Crohn's disease demonstrated little proliferation in response to this antigen but marked suppressor activity (79 +/- 13%). How the immunomodulatory effects of this antigen relate to the pathogenesis of the inflammatory bowel diseases remains to be determined.


PARA's SUMMARY

DATA IN THIS PAPER DEMONSTRATES THAT THE IMMUNE RESPONSE TO MAP IS SUPPRESSED IN ACTIVE CD ALLOWING THE ORGANISM TO MULTIPLY UNCHECKED. SIMILAR TYPES OF IMMUNE TOLERANCE RESPONSES ARE INDUCED IN OTHER INFECTIOUS DISEASES. THIS SUGGESTS A LINK BETWEEN MAP AND CD.


Source: http://www.crohns.org/articles/1991_02_320-5_cei.htm   Contact PARA: http://www.crohns.org/contact.htm
Paratuberculosis Awareness & Research Association